پاسخ ایمونولوژیک در لنفادنیت ناشی از تلقیح واکسن ب.ث.ژ

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Post BCG-adenitis is one of the most common complications of BCG&nbsp;vaccination, however the precise underlying immunologic response has not&nbsp;clarified yet. &nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; To determine the immunologic response in these patients, 56 patients&nbsp;with BCG adenitis and 46 healthy infants (as the control group) were&nbsp;enrolled in this study. The age range was between 2 months to 2 years and&nbsp;all cases had been vaccinated with Pasteur strain of BCG at birth. The&nbsp;tuberculin test was performed for both the patients and the control group,&nbsp; using 0.1 ml of PPD-S antigen with Mantoux method. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; There was a significant difference between the two groups (P<0.001)&nbsp;&nbsp;&nbsp; showing a median in duration of 19.7 mm for patient group versus 8.5 mm&nbsp; for control one . &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The high degree of delayed hypersensitivity reaction is most likely the&nbsp;cause of necrosis and lymph node enlargement. poptosis and imbalance&nbsp;between Th1 and Th2 responses of T-cell lymphocytes cab be considered as&nbsp;the underlying cause for the results obtained; however the regulatory&nbsp; mechanisms, especially the genetic controlling basis for immunologic&nbsp;response and immune cell analysis is further warranted to find the exact&nbsp;controlling mechanisms for the observed differences. For finding&nbsp;the exact&nbsp;&nbsp;&nbsp; causes of BCG lymphadenitis and Immunologic response in two groups ,&nbsp;determination of apoptosis cytokines and Th-cells activity in another study is&nbsp;highly suggested .